Tackling
Complexity in Natural, Biological and Socio-technical Systems

The Complex Systems and Networks Lab is headed by Prof. Yamir Moreno. The Lab is part of the Institute for Biocomputation and Physics of Complex Systems (BIFI) at the University of Zaragoza. The core of our research activity is aimed at investigating the laws governing the structure and dynamics of complex networked systems. We are actively researching on subjects such as: Epidemic spreading, including interacting and multi-pathogen diseases, the epidemiology of TB transmission, the analysis of biological, economic and socio-technical systems, the use of Big Data, the foundations of multilayer networks and systems, the theoretical and experimental basis of evolutionary game dynamics and human collective phenomena (see our dedicated web-page at http://nectunt.bifi.es), the analysis of nonlinear dynamics on networked systems and, lately, on some problems within the Systems Biology’s domain. You will find more specific information about all the previous research lines in the different sections of our webpage.

The understanding of human collective phenomena is of paramount scientific and technological importance. The colossal amount of digital data (Big Data) nowadays available is revolutionizing the way we study these phenomena. On its turn, new methods to efficiently deal with the data are called for. In Cosnet, we study the emergence and evolution of large-scale human behavior, the structure and dynamics of online social networks, and several kinds of diffusion processes on social systems.

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Understanding and predicting how diseases unfold and evolve is a long-standing research challenge. We aim at developing more accurate models to tackle the latter problem. To this purpose, we collect data from different sources, investigate on how to make classical epidemiological models more sophisticated and detailed and develop new theoretical and computational frameworks to deal with multi-scale diseases. Finally, a central point of our research agenda is the modeling of TB spreading.

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Systems Biology is a powerful approach for a better understanding of the interplay between the structure and dynamics of biological systems. In this area, we mostly study the topology and functioning of regulatory networks. Additionally, one of our main goals is to deepen into the mechanisms that underlie and promote human cooperative behavior in different contexts through experimentation. From a theoretical point of view, we address this problem using evolutionary game dynamics.

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This area is devoted to the study of several dynamical processes, mainly from a modeling perspective. For many years, we have studied network structure, as well as critical and synchronization phenomena and we continue to research on these topics. However, we are now more concentrated on the computational and theoretical study of so-called multilevel systems, which are made up by several layers each one representing a different topological instance of the system being modeled.

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Alfonso de Miguel-Arribas, Alberto Aleta, Yamir Moreno, “Interplay of epidemic spreading and vaccine uptake under complex social contagion”, Physical Review E 112, 014308 (2025).
Jorge P. Rodríguez, Alberto Aleta, Yamir Moreno, “Multilayer networks describing interactions in urban systems: a digital twin of five cities in Spain”, Scientific Data 12, 1227 (2025).
Xiangrong Wang, Dan Lu, Weina Xu, Hongru Hou, Zongze Wu, Yanqing Hu, Yamir Moreno, “Predicting critical behaviors of complex dynamic systems via learning the governing mechanism”, Chaos, Solitons and Fractals 198, 116515 (2025).
Henrique F. de Arruda, Kleber A. Oliveira, and Yamir Moreno, “Dynamical opinion clusters exploration suite: Modeling social media opinion dynamics”, SoftwareX 30, 102136 (2025).
Francisco A. Rodrigues, Thomas Peron, Colm Connaughton, Jurgen Kurths, and Yamir Moreno, “A machine learning approach to predicting dynamical observables from network structure”, Proceedings of the Royal Society A 481, 20240435 (2025).
Tiago Martinelli, Alberto Aleta, Francisco A. Rodrigues, and Yamir Moreno, “An informational approach to uncover the age group interactions in epidemic spreading from macro analysis”, Physical Review E 110, 064321 (2024).
Yikang Lu, Alberto Aleta, Chunpeng Du, Lei Shi, Yamir Moreno, “LLMs and generative agent-based models for complex systems research”, Physics of Life Reviews 51, 283-293 (2024).
Henrique F. de Arruda, Kleber A. Oliveira, and Yamir Moreno, “Echo chamber formation sharpened by priority users”, iScience 51, 111098 (2024).
Elena Candellone, Alberto Aleta, Henrique Ferraz de Arruda, Erik Meijaard, and Yamir Moreno, “Characteristics of the vegetable oil debate in social-media and its implications for sustainability”, Communications Earth and Environment 5, 391 (2024).
Guilherme F. de Arruda, Alberto Aleta, and Yamir Moreno, “Contagion dynamics on higherorder networks”, Nature Reviews Physics 6, 468-482 (2024).
Claudia Payrató-Borrás, Carlos Gracia-Lázaro, Laura Hernández, and Yamir Moreno, “Beyond the aggregated paradigm: phenology and structure in mutualistic networks”, Journal of Physics Complexity 5, 025013 (2024).
Marcus Engsig, Alejandro Tejedor, Yamir Moreno, Efi Foufoula-Georgiou, and Chaouki Kasmi, “DomiRank Centrality: revealing structural fragility of complex networks via node dominance”, Nature Communications 15, 56 (2024).
Marco Pangallo, Alberto Aleta, R. Maria del Rio Chanona, Anton Pichler, David MartínCorral, Matteo Chinazzi, François Lafond, Marco Ajelli, Esteban Moro, Yamir Moreno, Alessandro Vespignani, and J. Doyne Farmer, “The unequal effects of the health–economy trade-off during the COVID-19 pandemic”, Nature Human Behavior 8, 264-275 (2024).
Ariadna Fosch, Guilherme Ferraz de Arruda, Alberto Aleta, Adria Descals, David Gaveau, Courtney Morgans, Truly Santika, Matthew Struebig, Erik Meijaard, and Yamir Moreno, “Replanting unproductive palm oil with smallholder plantations can help achieve Sustainable Development Goals in Sumatra, Indonesia”, Communications Earth & Environment 4, 378 (2023).
Mario Tovar, Yamir Moreno, and Joaquin Sanz, “Addressing mechanism bias in modelbased impact forecasts of new tuberculosis vaccines”, Nature Communications 14, 5312 (2023).
Guilherme Ferraz de Arruda, Giovanni Petri, Pablo Martin Rodriguez, and Yamir Moreno, “Multistability, intermittency, and hybrid transitions in social contagion models on hypergraphs”, Nature Communications 14, 1375 (2023).
Alberto Aleta, David Martin-Corral, Michiel A. Bakker, Ana Pastore y Piontti, Marco Ajelli, Maria Litvinova, Matteo Chinazzi, Natalie E. Dean, M. Elizabeth Halloran, Ira M. Longini, Jr., Alex Pentland, Alessandro Vespignani, Yamir Moreno, and Esteban Moro, “Quantifying the importance and location of SARS-CoV-2 transmission events
in large metropolitan areas”
, Proceedings of the National Academy of Sciences USA 119, e2112182119 (2022).
Guilherme Ferraz de Arruda, Lucas G. S. Jeub, Angélica S. Mata, Francisco A. Rodrigues, and Yamir Moreno, “From subcritical behavior to a correlation-induced transition in rumor models”, Nature Communications 13, 3049 (2022).
F. Battiston, E. Amico, A. Barrat, G. Bianconi, G. Ferraz de Arruda, B. Franceschiello, I. Iacopini, S. Kéfi, V. Latora, Y. Moreno, M. M. Murray, T. P. Peixoto, F. Vaccarino, and G. Petri, “The physics of higher-order interactions in complex systems”, Nature Physics 17, 1093-1098 (2021).
Unai Alvarez-Rodriguez, Federico Battiston, Guilherme Ferraz de Arruda, Yamir Moreno,
Matjaz Perc, and Vito Latora, “Evolutionary dynamics of higher-order interactions in social networks”, Nature Human Behaviour 5, 586-595 (2021).